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SCIENCE
Discovery of CBD, THC & the ECS

All mammals have receptors that respond to compounds from cannabis plants, including hemp, such as CBD and THC. Those receptors, the CB1 and CB2 receptors, are found throughout the body including in the brain, spinal cord, immune system, etc. Since the Endocannabinoid System (ECS) is made up partly of those receptors, what does the ECS actually do? The short answer is that the ECS keeps our bodies in a state of homeostasis, or balance.

Scientific support began for the homeostasis theory of the ECS with the cloning of a rat CB1 receptor in Dr. Tom Bonner’s laboratory at the National Institute of Health (NIH) in 1990[1], followed immediately by the human CB1 receptor by Dr. C.M. Gérard and colleagues in Brussels in 1991[2]. A second cannabinoid receptor named CB2 was also identified at this time[3]. What did we learn from these experiments? The ability to first clone both rat and human cannabinoid receptors, and the identification of a second type of cannabinoid receptor, allowed researchers to understand the differences of those receptors and then search for naturally occurring molecules that would activate them. These naturally occurring molecules turned out to be the specialized neurotransmitters we discussed in Part 1 of this series, called endocannabinoids.

This research path led to the discovery that the ECS is made up of three working parts to support proper functioning; the endocannabinoids, endocannabinoid inhibitors, and receptors. First, let’s discuss how endocannabinoids activate the ECS. There are two major endocannabinoids responsible for this activation: Anandamide (ah-nan-da-mide), which binds with CB1 receptors, and Arachidonoylglycerol, mostly referred to as 2-AG, which binds to both CB1 and CB2 receptors.

The second of the three parts of the ECS are enzyme inhibitors, molecules designed to stop or slow chemical reactions specifically designed to work on endocannabinoids. These enzyme inhibitors reduce endocannabinoid activation by altering Anandamide and 2-AG on the molecular level. The enzymes that reduce endocannabinoid activity are referred to as Fatty Acid Amid Hydrolase (FAAH) and Monoacylglycerol Lipase (MAGL). They inhibit endocannabinoid activity by changing the shape of Anandamide and 2-AG rendering the endocannabinoids ineffective and unable to bind with receptors.

The third part of the ECS are the CB1 and CB2 receptors. Each type of receptor is found in every part of the body but the CB1 are more abundant in the Central Nervous System (brain and spinal cord) and the CB2 are found in a higher concentration throughout the Peripheral Nervous System and on immune cells.

The role of the ECS is to maintain a stable and balanced internal environment despite fluctuations in the external environment. So, despite chaos affecting our everyday lives, our inner body strives to remain balanced. The ECS is our internal system that maintains homeostasis within the body, and it is thought that if the ECS fails, so, too, can your overall wellness.

The discovery of the ECS is one of the most stunning finds of the 20th century and scientists are only scratching the surface on everything it can teach us. Investigation into the ECS is ongoing, getting us closer to understanding how this robust system appears to support nearly every function of the body through endocannabinoid regulation and phytocannabinoid support.

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The ECS is our internal system that maintains homeostasis within the body, and it is thought that if the ECS fails, so, too, can your overall wellness.

CBD oil and lotion SCIENCE Discovery of CBD, THC & the ECS All mammals have receptors that respond to compounds from cannabis plants, including hemp, such as CBD and THC. Those

Ep. 62: CBD Oil-Paragon Recovery

28 мар 2019 · Clinically Pressed

CBD Oil has taken the health and wellness industry by storm. You can can find it everywhere. Our friends at Paragon Recovery decided to get in the game and do CBD Oil right. That includes doing their very own distillation of it to make sure it is as pure as you can get it (check out their Instagram). ​We sat down with Paul Schecklman to discuss what exactly CBD Oil is and how it can benefit you in your recovery. We get deep into some of the uses for it and exactly how it is working with your body to provide benefits that the industry is just starting to understand. If you have questions on it, this is a great resource to start with.​#complicatedsimpleLINK: https://www.youtube.com/c/clinicallypressed?sub_confirmation=1#complicatedsimple #progressive #openminded #PBE #EBP #noagenda #performance #training #nutrition #health #wellness #athlete #athletictraining #science #chiropractic #rehab #prevention #clinicallypressed— Support this podcast: https://anchor.fm/clinicallypressed/support

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REPLAY Ep. 72: Josh McLain-The Croc Doc

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Josh MClain is a physical therapist that takes a very unique approach to his work. First, he serves a lot of wrestlers that makes what he does unique just by the nature of the sport and the demand those athletes place on their body. Along with his work as a PT he also runs a venture of a traveling ninja warrior course.

Josh takes a completely different look at your pain and your movement and this is what makes what he does unique. Josh provides so much insight into how he approaches things differently in this episode. Great discussion.

#clinicallypressed #complicatedsimple #health #wellness #nutrition #performance #leadership #podcast #insight #AT #at4all #atchat #rehab #treatment #science #chiropractic #sportsscience #physicaltherapy #pt #crocdoc #wrestling #movement #totalbody #movementtherapy

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REPLAY: Jim Stoppani-Supplement Q & A

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After Jim Stoppani finished talking on the topic of Building a Safer Supplement Industry through Education while he was at UWL he opened it up to questions. Jim covered everything from continuing your education, to how Jym Supplement Science was built and how to create your own niche as you move along in your career. Great information on all fronts.

Please enjoy this replay.

#clinicallypressed #complicatedsimple #health #wellness #nutrition #performance #leadership #podcast #insight #AT #at4all #atchat #rehab #treatment #science #chiropractic #sportsscience #research

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REPLAY Ep. 22: Dynamic Neuromuscular Stabilization (DNS)

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We are going back to some of our most played episode on the podcast as we gear up for a relaunch of Clinically Pressed. Bringing more insight and thoughts to help people from clinicians to patients. More to come but until then, please enjoy these top replays.

This was a trip Kyle and Joel took to a Dynamic Neuromuscular Stabilization Level 1 course hosted by Midwest Rehabilitation Institute. After the first day we got to sit down with the instructor Brett Winchester and host Alex Earl and cover all kinds of topics.

We discussed more behind DNS and how both of them have utilized it in their practice and seen it evolve. We also talk about how both Brett and Alex have continued to learn but also made a conscious effort to work on being the best at what they do and what that takes. This is a great episode if you’re looking to up your game in any area. Check it out.

CBD Oil has taken the health and wellness industry by storm. You can can find it everywhere. Our friends at Paragon Recovery decided to get in the game and do CBD Oil right. That includes doing their… – Слушайте Ep. 62: CBD Oil-Paragon Recovery by Clinically Pressed моментально на планшете, телефоне или в браузере – загрузка не требуется.