Lamictal And CBD Oil Interaction
By Jonathan Post date
Drug interactions can be life threatening. That being said it is important that you consult a doctor before taking a new medicine on a daily basis. Your doctor may or may not allow you to consume a new drug with a previously prescribed medicine due to possible chemical interactions. One of the most common drug interactions is the lamictal and CBD Oil Interaction. This article will help you understand the composition and affects of the two products individually followed by the consequences of an interplay between the two substances.
What is CBD Oil?
Cannabidiol CBD Oil is a natural medicine extracted from the cannibas plant. It is proved to have many therapeutic benefits which can help reduce the effects of anxiety, depression and many other neurological disorders including Parkinson’s. CBD serums that are medically certified contain a small amount of THC also known as tetrahydrocannabinol.THC is a psychoactive element found in cannibas that makes you feel “high”. However, since CBD Oils only contain some traces of this substance, it will not have any psychoactive affects on the user. Here’s a list of some widely known benefits of CBD Oils:
Chronic Pain and Inflammation
People who have been suffering from chronic pain as a result of fibromyalgia have experienced relief after using CBD oil. This natural medicine prevents the degeneration of the nervous system and many studies show that CBD has helped in the treatment of sclerosis and has even helped reduce cancer pain.
CBD oils have been proven to have anti-seizure properties which can successfully treat children who have been suffering from drug resistant neurological disorders like epilepsy. In June 2018, the US Food and Drug Administration approved the prescription of a purified form of CBD oil known as “Epidiolex”. This has helped treat two severe and rare forms of epilepsy found in children at the age of 2 or older. These two forms of epilepsy known as the Darvet syndrome and the Gastaut syndrome generally don’t respond to any other type of anti-seizure medications.
Anxiety and depression
In 2015, the journal Neurotherapeutics proved that CBD Oil is beneficial for people suffering from anxiety and depression. This non-psychoactive compound can help cure some anxiety related behaviors like:
- Panic Disorder
- Substance abuse disorder
- Post-traumatic stress disorder (PTSD)
- Obsessive-compulsive disorder (OCD)
What is Lamictal?
Lamictal is a drug used alone or with other medicines to prevent and control the occurrence of seizures. It is also be used to reduce mood swings or avert bipolar disorders in adults. This drug is known as antiepileptic or anticonvulsant as it works on restoring the balance of substances found in the brain.
Before using this drug you need to make sure that you are not allergic to lamotrigine. If so, immediately stop the use of lamictal as it can lead to a life threatening rash especially in children or adults who are taking a very high dose. People using this medicine might have thoughts about suicide thus, regular visits to the doctor are a must. Also, ask your friends and family to monitor the changes in your mood. Furthermore, this product can reduce the effectiveness of hormonal birth control products including pills, patch or rings.
Drug Interaction – CBD & Lamictal
Cytochrome P450 is a family of enzymes that helps oxidize fatty acids and steroids. They are also important for hormone synthesis and breakdown. These enzymes can be induced or inhibited by drugs which can result into clinically significant drug to drug interactions that can cause therapeutic failures or other unanticipated adverse reactions.
Cannabidiol can inhabit the ability of the P450 to metabolize certain drugs and in this case the metabolization of lamictal. Once the ability of P450 to metabolize is reduced, it leads to higher levels of lamictal in the blood which can lead to an overdose. An overdose of lamictal can cause troubled breathing, unusual eye movements and loss of unconsciousness. If any of this symptoms occur, take the patient to the hospital immediately as it may be life threatening.
Using CBD Oil with lamictal can result into dizziness, drowsiness and difficulty in concentrating. This is due to the reduced ability of your body to breakdown lamictal for use against the occurrence of seizures. The affects are most prominent amongst elderly people who may also suffer from impairment in thinking or accessing a certain situation. In other words, their motor coordination is severely affected so it takes them longer to understand or react to a certain situation. This means that they will need a guardian with them at all times.
Safe Use of Drugs
Before using any medicines it is important that you make an appointment with your doctor. While you may think that using two drugs at a time will help reduce the symptoms of the disease, this is not the case. Drug interactions are real and dangerous; they can lead to life threatening situations. In some cases the adverse effects of a drug interaction may not appear at first; even though your body knows that there is a drug imbalance in your body. This is more dangerous since you may not know that something is wrong before the situation becomes serious. However in other drug interactions, the adverse effects are fast and prominent. You may suffer from:
- A Skin Rash
- Severe Nausea and Vomiting
If your body shows any of the above symptoms, it is time to pay a visit to a doctor and stop the use of CBD Oils completely.
You must understand that CBD is a natural medicine and cannot be used in place of any other medicine that has been prescribed by the doctor. This is mainly because the drug has different effects on different people. It might work great for some people and may not have any benefits for others. Thus, it is foolish to depend on CBD to cure a disease. While it may suppress the symptoms, it is not an alternative to allopathic medicines.Lamictal And CBD Oil Interaction By Jonathan Post date Drug interactions can be life threatening. That being said it is important that you consult a doctor before taking a new medicine on
CBD vs. Lamictal for Seizures & Bipolar Disorder: About Interactions & Better Options
Lamotrigine, sold under the brand name Lamictal, is an anti-epileptic (AED) and anti-convulsive medication, prescribed as a standalone or supplementary medication, for treating and controlling epileptic seizures and bipolar disorder.
Studies indicate that Lamictal restores the balance of the natural substances in the brain and slows down the electrical signals that otherwise go on overdrive or trigger brain signals that have completely stopped during seizures or extreme mood swings. This helps reduce the intensity and frequency of seizures as well as keeps mood swings under control.
There is also some evidence of lamotrigine having clinical efficacy in certain neuropathic pain treatments.
Due to its mood-stabilizing properties, physicians prescribe lamotrigine to control and avert extreme mood swings of bipolar affective disorder (BPAD) and borderline personality disorder (BPD).
Studies mostly indicate that Lamictal is a safe and effective anti-convulsive supplement for both unipolar and bipolar depression, as well as rapid cycle manic-depression. There is also evidence of lamotrigine helping patients with Lennox-Gastaut syndrome and related epilepsy syndromes.
However, patients have often encountered quite a few adverse events, including some serious, life-threatening side-effects.
Lamictal’s Safety Issues Causing Concern Among Patients
Like most pharmaceutical drugs, Lamictal, too, has several side-effects. While some are benign, such as dizziness, lethargy, nausea, and headaches, others may be much more critical. These vary from increased sensitivity of muscles and sensory nerves and jaundice to lethal skin rashes, suicidal behavior, and even sudden unexplained death.
Even the US Food and Drug Association (FDA) had warned that lamotrigine use “can cause a rare, but very serious reaction that excessively activates the body’s infection-fighting immune system”, leading to rashes or blisters, that could very quickly turn into an emergency situation and even cause death, if undiagnosed or untreated in time.
Can CBD Address These Concerns?
Are you struggling with the side effects of Lamictal and looking for a safer option, or are you keen on ridding yourself of your medical condition through a natural remedy?
Either way, you’re right to be apprehensive about your AED medications. Such adverse effects of medications often complicate life and reduce its quality. A lot of people look for safer options, as should you.
Quite a few anecdotal and scientific evidence have emerged that reflect well on natural extracts, like Cannabidiol (CBD), as safer, yet effective alternatives to conventional treatments.
CBD has been proven to alleviate the underlying causes of mood disorders, epilepsy, and other neuropsychiatric disorders.
Can Cannabidiol Be An Effective Remedy?
CBD has emerged as a potent remedy to treat many common health issues, without experiencing the typical mind-altering effects of some cannabis compounds or prescription drugs. Interestingly, some of the most well-researched uses of CBD relates to potential therapy of neuropsychiatric and neurological disorders.
CBD has been found to be effective in helping manage pain, alleviating depression, reducing anxiety, bipolar disorder, and other neuropsychiatric disorders.
Let’s discuss what the researchers have found so far…
- A 2015 clinical trial, published online in The Lancet, Neurology, verified the efficacy of CBD on patients, with treatment-resistant epilepsy, who had previously been on regular doses of AEDs. The studies indicated that the patients, who received oral CBD between 5mg – 50mg/kg/day, showed a reduction in the frequency of seizures. The tests also showed CBD was adequately safe, even on children.
- Another 2017 randomized controlled trial, published in The New England Journal of Medicine, revealed that CBD oils were effective in reducing convulsive-seizures among children with a rare epileptic disorder, called Dravet Syndrome. However, it also indicated “higher rates of adverse events”.
- Another study, published in the New England Journal of Medicine in 2018, found better results when CBD (10 – 20 mg/kg/day) was combined with regular AEDs to treat seizures in 225 Lennox-Gastaut syndrome patients. This test too showed some cases of liver damage due to CBD use.
CBD has also been proven to have some very positive effects on our moods, particularly in reducing depression and anxiety, like those associated with BPAD and BPD.
- According to a 2018 study, published in the “Progress in Neuro-Psychopharmacology & Biological Psychiatry” indicated that small doses of CBD, coupled with equal doses of serotonergic agents, exhibits “antidepressant-like effects”, indicating that CBD may also be an effective agent of depression therapy.
- According to a 2005 review, published in the Journal of Pharmacology, CBD, combined with low doses of THC, could be “therapeutic in bipolar patients with psychotic symptoms, and (its) anticonvulsant and protective effects may have a mood-stabilizing action similar to other anticonvulsants of proven value in BAD”.
- However, a 2010 case report, published in the same journal (Journal of Pharmacology), indicated that “CBD may not be effective for the manic episode of BAD”.
Apart from these findings, some studies also point to CBD’s neuroprotective properties, while others indicate that this cannabinoid supports neurogenesis and nerve cell regeneration, besides activating several neural pathways that lead to lowering of depression and anxiety, as well as reversing damage caused by psychotic disorders.
CBD has numerous properties that seem to replicate the functions of many pharmaceutical medications. However, in complex disorders, like epilepsy and BPAD, any one drug or substance often proves ineffective.
So, patients often consider taking CBD along with AEDs, NDRIs, or SSRIs. Now the question arises: Can you use CBD while you are on Lamictal?
CBD-Lamictal Interaction: Can the two be mixed?
CBD tends to interact with most pharmaceutical drugs, especially the ones that come with the grapefruit warning.
CBD evidently inhibits the functions of certain Cytochrome P450 (CYPs) isozymes, a family of liver enzymes responsible for drug metabolism, thus hindering the breakdown of those drugs.
This leads to the drug staying in the bloodstream for an extended period, causing potential harm to the body, including a possible drug overdose and other medical complications. Is Lamictal one such drug?
So, Does CBD Interact With Lamictal?
Some studies indicate that there doesn’t seem to be any obvious signs of drug interaction when you use Lamotrigine with CBD.
However, is that the whole truth?
While it’s always best to consult your doctor about possible drug interactions, here are a few research papers and trial data that may interest you:
- According to a Full‐Length Original Research, published in the Epilepsia – The Official Journal of the International League Against Epilepsy on August 6, 2017, “there were no significant changes in drug levels with CBD dose titration in the other AEDs analyzed”, including lamotrigine.
An interesting finding sheds more light on the effects of CBD on patients with treatment-resistant epilepsy (TRE).
- A 2019 clinical trial, published in the Epilepsy & Behavior, not only exhibited no drug-drug interaction, it even displayed CBD’s abilities to lower seizure frequency and severity in patients with TRE, irrespective of AEDs. The trial proved that while AEDs were unable to make much difference, with or without cannabidiol, CBD use alone showed significant improvement in the patients.
Nevertheless, lamotrigine, among other newer AEDs seems to stimulate the metabolism of hormonal contraceptive pills, involving CYP3A4, which is one of the enzymes that CBD inhibits.
Besides, some studies on CBD also show that it may inhibit an enzyme, known as UGT2B7 (UDP-Glucuronosyltransferase-2B7), which is necessary for the metabolization of lamotrigine.
This, however, suggests a possible CBD-Lamictal interaction, leading to an increase in the concentrations of Lamictal in the bloodstream, thereby increasing the risk of further aggravation of Lamictal-related side effects.
Besides, the only FDA-approved CBD drug, Epidiolex, in its “prescribing information”, urges users to avoid lamotrigine, as “in vitro data predict drug-drug interactions with…UGT2B7”.
Before We Go…A Word Of Advice
Some people use CBD oils with prescription drugs, like lamotrigine, to alleviate the side-effects caused by such drugs, while others are more inclined towards replacing lamotrigine with CBD oil. In all likeliness, CBD does seem to be a helpful remedy to relieve the symptoms without causing too many side effects like most drugs.
Notwithstanding these benefits, CBD is still a reasonably new prospect in the field of medicine.
While there isn’t much evidence of severe drug reactions after consuming CBD oils with Lamictal other than some very mild side-effects, complaints of side-effects by patients, who regularly take Lamictal, are numerous as they are often.
In contrast, scientific research and anecdotal evidence seem to portray CBD as a potentially safe alternative.
Nevertheless, both epilepsy and bipolar disorders, two critical conditions that Lamictal is meant to treat, need proper medical care, which CBD may not be capable of providing given the inadequate regulation of CBD products and lack of sufficient scientific knowledge.
As of now, Epidiolex is the only FDA-approved CBD medication to be allowed for the treatment of two rare forms of epileptic disorders. It has also been approved to treat tuberous sclerosis complex patients.
Whether CBD, in general, can replace Lamictal or be administered along with it is still debatable.
So, our word of advice to our readers would be:
- Do your research to better understand all the pros and cons of CBD use for epilepsy and/or bipolar affective disorder.
- Consult your doctor before you self-administer CBD oil for either disorder.