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Isomerization Of Cbd To Thc

MirrorZen

Cannabidiol to THC – simple
(Rated as: excellent)

Cannabidiol (CBD), the main cannabinoid constituent of fibre hemp has been converted (isomerized) to delta-9 and delta-8-tetrahydrocannabinol employing a variety of conditions.
Many of these procedures require chemicals that are hard to come by such as dichloromethane (DCM) and boron trifluoride etherate.
The following is a simple and fast procedure for the synthesis of delta-8- or delta-9-THC from CBD:

Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.
Let solution stand at room temperature.
After 3 hours CBD has been converted into 52% delta-9-THC and 2% delta-8-THC.
After 3 days a mixture of 15% delta-9-THC, 54% delta-8-THC, 10% delta-8-iso-THC and 10% CBD has formed.
Work up:
Pour into water (100ml or more) and add cautiously with stirring (foaming!) enough sodium bicarbonate (15g should do) to raise the pH above 7. Extract with petrol ether, wash with water, evaporate solvent to get mixture of starting CBD and predominantly delta-9- or delta-8-THC with some other byproducts depending on the reaction time.
Can chromatograph on silica gel with 1 to 2% ether in petrol ether for purification.

CBD can also be converted into delta-9-THC with anhydrous ZnCl2 at 150° without solvent (perform reaction best in vacuum as product is sensitive to oxidation):

Heat 0.5g CBD with 0.09g anhydrous ZnCl2 under vacuum with stirring.
After 2 hours 40 to 50% delta-9-THC have formed.

DemonTrich
MirrorZen
Graywolf

We isomerized using sulfuric acid, but haven’t continued to do so because most of the material that we work with is already high in THC and low in CBD, so not much gain.

We are actually growing strains specifically for the CBD that we use in topicals, or using CBD from Hemp.

kansabis
MirrorZen
Graywolf
kansabis
ZenChem

We isomerized using sulfuric acid, but haven’t continued to do so because most of the material that we work with is already high in THC and low in CBD, so not much gain.

We are actually growing strains specifically for the CBD that we use in topicals, or using CBD from Hemp.

ZenChem
CBNight

Out of curiosity, how would you then isolate thc from the Zinc Chloride solution?

Cannabidiol to THC – simple
(Rated as: excellent)

Cannabidiol (CBD), the main cannabinoid constituent of fibre hemp has been converted (isomerized) to delta-9 and delta-8-tetrahydrocannabinol employing a variety of conditions.
Many of these procedures require chemicals that are hard to come by such as dichloromethane (DCM) and boron trifluoride etherate.
The following is a simple and fast procedure for the synthesis of delta-8- or delta-9-THC from CBD:

Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.
Let solution stand at room temperature.
After 3 hours CBD has been converted into 52% delta-9-THC and 2% delta-8-THC.
After 3 days a mixture of 15% delta-9-THC, 54% delta-8-THC, 10% delta-8-iso-THC and 10% CBD has formed.
Work up:
Pour into water (100ml or more) and add cautiously with stirring (foaming!) enough sodium bicarbonate (15g should do) to raise the pH above 7. Extract with petrol ether, wash with water, evaporate solvent to get mixture of starting CBD and predominantly delta-9- or delta-8-THC with some other byproducts depending on the reaction time.
Can chromatograph on silica gel with 1 to 2% ether in petrol ether for purification.

CBD can also be converted into delta-9-THC with anhydrous ZnCl2 at 150° without solvent (perform reaction best in vacuum as product is sensitive to oxidation):

Heat 0.5g CBD with 0.09g anhydrous ZnCl2 under vacuum with stirring.
After 2 hours 40 to 50% delta-9-THC have formed.

therealAries

Cannabidiol to THC – simple
(Rated as: excellent)

Cannabidiol (CBD), the main cannabinoid constituent of fibre hemp has been converted (isomerized) to delta-9 and delta-8-tetrahydrocannabinol employing a variety of conditions.
Many of these procedures require chemicals that are hard to come by such as dichloromethane (DCM) and boron trifluoride etherate.
The following is a simple and fast procedure for the synthesis of delta-8- or delta-9-THC from CBD:

Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.
Let solution stand at room temperature.
After 3 hours CBD has been converted into 52% delta-9-THC and 2% delta-8-THC.
After 3 days a mixture of 15% delta-9-THC, 54% delta-8-THC, 10% delta-8-iso-THC and 10% CBD has formed.
Work up:
Pour into water (100ml or more) and add cautiously with stirring (foaming!) enough sodium bicarbonate (15g should do) to raise the pH above 7. Extract with petrol ether, wash with water, evaporate solvent to get mixture of starting CBD and predominantly delta-9- or delta-8-THC with some other byproducts depending on the reaction time.
Can chromatograph on silica gel with 1 to 2% ether in petrol ether for purification.

CBD can also be converted into delta-9-THC with anhydrous ZnCl2 at 150° without solvent (perform reaction best in vacuum as product is sensitive to oxidation):

Heat 0.5g CBD with 0.09g anhydrous ZnCl2 under vacuum with stirring.
After 2 hours 40 to 50% delta-9-THC have formed.

CBD converted to THC. Thats not possible all conpounds are converted from CBGa Cannabigerolic Acid to either chemotypes (CBDa) or (THCa)

Bless up and keep on learnin’ the facts are always helpful in keeping misinformation far away

Everything I post is for educational purposes and for entertainment purposes as well I am obsessed with cannabis and want to learn as much as possible

I know this is old news for the chem heads, but I know it's still not being used by the large percentage. It will only get more popular. Isomerizing cbd to…