Can You Build a Tolerance to CBD?
Can You Build a Tolerance to CBD?
Building a strong tolerance–or reverse tolerance—to CBD may actually be beneficial in the long run.
Researchers are finding that CBD oil may be able to treat the symptoms of a whole host of diseases and conditions. Sufferers of depression, anxiety, arthritis, chronic pain, and even Alzheimer’s may all find relief by using CBD oil.
A common question that comes up when people first consider trying CBD oil is whether or not you can develop a CBD tolerance over time.
CBD isn’t cheap and health insurance isn’t likely to cover it any time soon, so the thought of having to take more and more over time to get the same relief can be daunting.
Here’s the currently available information on long-term CBD oil use and the potential for developing a tolerance.
Is It Possible to Build a Tolerance to CBD?
While research has concluded that long-term use of cannabis containing tetrahydrocannabinol (THC) results in a THC tolerance, cannabidiol (CBD) appears to work in the opposite direction. Studies and scientific reviews of CBD oil use suggest you likely won’t build a tolerance to CBD, and long-term use may actually result in reverse tolerance.
“Reverse tolerance” refers to the phenomenon in which a person needs less of a substance to feel its effects the more they are exposed to it. So over time, CBD oil users may find relief from their symptoms with lower and lower doses.
CBD is one of over 100 phytocannabinoids found in the cannabis plant. Phytocannabinoids are chemically similar to the endocannabinoids produced by the human body; both types of cannabinoids interact with your body’s endocannabinoid system (ECS). While more research needs to be done, it is believed that because CBD indirectly activates cannabinoid receptors in the ECS without binding to them, it increases the number of endocannabinoids naturally produced by your body over time. The more endocannabinoids available, the less CBD oil you need to feel the benefits of a well-functioning endocannabinoid system.
Since research on CBD oil and reverse tolerance is still in its infancy, anecdotal evidence and your own personal experimentation are going to be your best resources on the topic. Even though CBD oil will not get you “high”, start off with a lower dose if you’re testing out your tolerance. It will be easiest to track and measure your ideal dosage by gradually increasing the amount you take over the course of a few weeks or months. If the benefits you’re feeling start to plateau even as your dosage goes up, you’ll know you’ve accumulated some tolerance to CBD, and it could be time to try lowering your dosage.
Effects of Long-Term CBD Use
Until fairly recently, laws against the use of cannabis and marijuana have limited the number of longitudinal studies examining long-term use of CBD. A majority of the clinical research on the effects of CBD oil does not include a testing period longer than a few months. Hopefully though, as the laws around cannabis, hemp, and CBD continue to shift, more information will become available.
Even though there’s a lack of research on long-term CBD oil use, other scientific and medical studies have yielded promising results in terms of CBD’s safety and efficacy. CBD oil is generally considered to present little to no risk for addiction or side effects. The World Health Organization (WHO) has even gone as far as to state “CBD is generally well tolerated with a good safety profile.”
There is a great deal of evidence that suggests that CBD oil may be a safer, more effective way to treat conditions that require long-term treatment, like depression and chronic pain.
CBD for Depression
Depression has become incredibly common over the years, and the medications prescribed to treat its symptoms often result in unpleasant side effects. Compounding the issue, stopping antidepressant medications can often result in withdrawal symptoms. CBD is showing promise as an effective alternative option for those dealing with depression.
In one animal study, CBD was found to have antidepressant-like effects in mice by helping to activate the 5-HT1A receptor, which is normally activated by the feel-good neurotransmitter serotonin. In another study, CBD was found to increase the amount of the “bliss molecule,” anandamide, in the brain. Anandamide is the neurotransmitter most commonly associated with feelings of joy and happiness.
While long-term use of antidepressants can lead to weight gain, loss of sexual function, emotional numbness, withdrawal, and even addiction, CBD oil has not been shown to produce any of these negative side effects.
CBD for Chronic Pain
Another potential long-term use case for CBD oil is in the treatment of chronic pain. Suffers of chronic pain are frequently prescribed medications with significant side effects, many of which are habit-forming. Those that wish to come off pain medications are often faced with debilitating withdrawal symptoms on top of the pain they’re already dealing with.
CBD oil, in comparison, is beginning to look like a great alternative treatment for pain. In a comprehensive review of clinical trials examining CBD’s effect on difficult-to-treat pain, it was concluded that CBD offers a promising alternative or complement to current treatments for pain management. And given the possibility for reverse tolerance, CBD oil dosages may be tapered down over time, mitigating any potential risks of long-term use.
How to Get Continual Benefits from CBD Oil
Since you’re unlikely to build a strong tolerance to CBD oil, and may in fact be dealing with reverse tolerance the more you use, how can you continue to get the most from your CBD product?
In order to properly understand the effects CBD is having on you, it is recommended that you keep a daily log. Each time you take CBD oil, write down the amount you have taken and when you have taken it. Write down any effects you experience, including any changes you notice in your physical body or mental processes. Writing these developments down will be crucial to finding your ideal dosage and deciding if CBD oil right for you in the long-run.
When it comes to choosing a CBD product, don’t be afraid to experiment with different strains, brands, and delivery formats (e.g. CBD vapes, CBD oil drops, CBD edibles). You may have to try a few different products before you find the one that works best for you. Remember to note how different products affect you—maybe a CBD vape is great for when you’re feeling anxious, but CBD drops are best for relieving pain. Finding the right CBD product(s) for your needs is a personal and exciting journey!
One of the best ways to see continual CBD benefits is to mix up your CBD oil delivery formats. In fact, you may find it most effective to use a combination of products. A CBD oil tincture or capsule might be ideal for daily use, while a CBD flower or CBD vape pen are best for on-the-spot relief.
Always talk to your doctor before you use CBD oil. While CBD oil is generally safe, there are some possible drug interactions that should be carefully monitored. If your doctor approves your CBD use, and you’re logging your experiences, you both can quickly narrow down the reasons for any negative effects.
CBD Oil Dosage
You should always follow the dosage recommendation included with your CBD oil product. If you’re looking for a more personal assessment, you might also consider speaking with a naturopathic doctor who can give you a specific dosing recommendation for your condition, age, weight, and experience with CBD.
To take some of the guesswork out of figuring out the right CBD oil dosage, we at CBD Oil Review have come up with a general recommendation, having tested and reviewed hundreds of CBD oil products:
The CBD Oil Review Serving Standard is 25mg of CBD, taken twice daily.
If the desired effect is not reached at this dosage, we recommend slowly increasing your dose by 25mg every 3 to 4 weeks.
Once you’ve found an effective dose that works for you, you probably won’t need to increase it. Because of reverse tolerance, you may even find that with repeated use you can actually decrease the amount of CBD you take over time.
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Learn if your body can build a tolerance—or reverse tolerance—to CBD oil and how to maximize its benefits in the long term.
Can You Build Up A Tolerance To CBD?
Most people taking cannabidiol are told that taking a regular, repeated dose is the key to getting the right results. But could taking CBD so regularly cause people to build up a tolerance and therefore constantly require a stronger dose? In this article, we take a closer look at whether it’s possible to build up a tolerance to CBD.
Understanding cannabinoid tolerance
It is possible to build up a tolerance to some cannabinoids, like THC. THC is the main psychotropic compound in cannabis and delivers its effects by binding to CB1 receptors. These receptors work like little locks that are designed to be opened by endocannabinoids like anandamide and 2-AG, but some plant-derived cannabinoids with a similar structure (like THC) can also bind directly to them.
When THC binds to these receptors, it can mimic endocannabinoids and cause the endocannabinoid system to down-regulate in order to avoid becoming overactive. The ECS down-regulates by producing fewer endocannabinoids and fewer endocannabinoid receptors.
As a result, people who regularly consume these cannabinoids may find that they need increasingly larger doses in order to feel the same effects. This can also affect the endocannabinoid system’s ability to learn and adapt to factors like stress as it has become over-dependent on THC.
What about CBD? Can it cause tolerance?
CBD is very different from other cannabinoids, and we’re still a ways away from completely understanding this compound and its actions throughout the body. What we do know, however, is that it doesn’t bind to cannabinoid receptors in the same way as THC. Instead, it acts via numerous other chemical pathways. Some resources suggest that CBD can activate over 60 different molecular pathways in the body.
So far, studies indicate that CBD can affect serotonin receptors, vanilloid receptors, GABA receptors, gamma receptors, and more. Other studies show that CBD can inhibit a process known as reuptake, and thereby temporarily increase the amount of certain chemicals in the brain, such as serotonin and anandamide.
While CBD doesn’t bind to endocannabinoid receptors, it can still interact with them indirectly. For example, studies have shown that it can work as an inverse agonist of CB1 receptors. Nonetheless, there is no current research claiming that CBD causes users to develop tolerance. Instead, it’s widely regarded as a safe, non-toxic compound that’s very well-tolerated. A 2011 study published in the journal Current Drug Safety stated that human trials testing various dosages of CBD didn’t cause side effects or tolerance.
What is reverse tolerance?
In fact, some research suggests that CBD may cause reverse tolerance. Unlike THC, which occupies the role of endocannabinoids and can down-regulate the endocannabinoid system, CBD can increase endocannabinoid levels (e.g. by inhibiting reuptake). Hence, over time, users may find that they need lower doses of CBD to get the same results. Though this is currently just theory.
Unfortunately, our understanding of CBD and the endocannabinoid system is far from complete. There’s still a lot more research needed before we can begin making concrete statements about CBD and how it works inside the body. However, current research shows that CBD doesn’t cause tolerance like other cannabinoids might.
It's possible to build up a tolerance to some cannabinoids, but what about CBD? In this article, we explore whether cannabidiol can cause tolerance.