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Does CBD Interact With Trazodone Or Effexor?

In our latest question and answer, the pharmacist discusses whether or not CBD (cannabidiol) interacts with trazodone or Effexor (venlafaxine).

Anna asked

Hello, could you tell me if I can take CBD oil (the bottle contains 500mg pure CBD, one drop contains 1,25 mg) and vitamins/supplements (C,K,B6,B12,B3,magnesium) with these medications: – Effexor 150 mg prolonged release (in the morning)- Trittico (trazodone) 75 mg prolonged release (in the evening)I’m afraid of potential interactions.

Answer

There are a few potential interactions between CBD (cannabidiol) and the two medications in your inquiry, trazodone and Effexor (venlafaxine). Unfortunately, there isn’t a lot of data regarding CBD interactions with specific drugs so we often need to extrapolate what we know about how they are metabolized to determine whether or not there are potential drug interactions to be concerned about.

Even then, we don’t know much about CBD in general. We do know that CBD can inhibit certain metabolizing enzymes, a common characteristic of many drug interactions. However, there are many studies that theorize that while CBD does inhibit metabolizing enzymes, it takes extraordinarily large doses to do so and the inhibition is not to a significant extent for most individuals.

Nevertheless, until more studies are completed, CBD should be used cautiously in those taking prescription medications. Below, we discuss CBD and potential drug interactions with trazodone and Effexor in more detail.

What Is CBD (Cannibidiol)?

Cannabidiol, also known as CBD, is a non-euphoric constituent of cannabis, also known as marijuana.

While THC (delta-9-tetrahydrocannabinol) is likely more well-known due to its psychoactive and euphoric effects, CBD makes up almost 40% of many cannabis extracts and has a wide range of potential benefits when used medicinally, although more studies are needed to better understand the compound.

The amounts of CBD used in studies range greatly (from 1 mg to over 600 mg), but there is preliminary positive evidence for a variety of indications, including:

  • Anxiety
  • Epilepsy
  • Chronic pain
  • Seizures
  • Multiple Sclerosis
  • Insomnia
  • Parkinson’s Disease

Further adding to the potential benefit of CBD, is the fact that it is considered CBD is considered “non-euphoric”, even at high doses. In fact, many studies have shown that when combined with THC, CBD can decrease some unwanted effects, such as cognitive impairment.

CBD has recently has exploded in popularity, with many different products available over the counter. With this, it is important to consider potential drug interactions with prescription medication, such as Effexor and trazodone.

CBD (Cannibidiol) Drug Interactions

The two main constituents of marijuana, THC and CBD, are known to be metabolized by the cytochrome P450 system, the major enzymes involved in drug metabolism. Specifically, studies have shown that CBD can inhibit:

  • CYP2C9
  • CYP2C19
  • CYP3A4
  • CYP2D6
  • CYP1A1
  • CYP1A2

Metabolizing enzyme inhibition often leads to increased concentrations of drugs that are typical substrates for a particular enzyme. The majority of prescription medications are metabolized by CYP enzymes, therefore potential interactions are plentiful.

Effexor – CBD (Cannibidiol) Interaction

. studies indicate that the formation of ODV (O-desmethylvenlafaxine) is catalyzed by CYP2D6; this has been confirmed in a clinical study showing that patients with low CYP2D6 levels (“poor metabolizers”) had increased levels of venlafaxine and reduced levels of ODV compared to people with normal CYP2D6 (“extensive metabolizers”). The differences between the CYP2D6 poor and extensive metabolizers, however, are not expected to be clinically important because. venlafaxine and ODV are pharmacologically approximately equiactive and equipotent.”

In our latest question and answer, the pharmacist discusses whether or not CBD (cannabidiol) interacts with trazodone or Effexor (venlafaxine).