advil and marijuana

Drug Interactions between cannabis and ibuprofen

This report displays the potential drug interactions for the following 2 drugs:

  • cannabis
  • ibuprofen

Interactions between your drugs

No interactions were found between cannabis and ibuprofen. This does not necessarily mean no interactions exist. Always consult your healthcare provider.


A total of 378 drugs are known to interact with cannabis.

  • Cannabis is in the drug class illicit (street) drugs.
  • Cannabis is used to treat the following conditions:
    • AIDS Related Wasting
    • Muscle Spasm
    • Nausea/Vomiting, Chemotherapy Induced
    • Pain


A total of 358 drugs are known to interact with ibuprofen.

Drug and food interactions

cannabis (Schedule I substance)

Applies to: cannabis

Alcohol can increase the nervous system side effects of cannabis (Schedule I substance) such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cannabis (Schedule I substance). Do not use more than the recommended dose of cannabis (Schedule I substance), and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See Also

  • Cannabis Drug Interactions
  • Ibuprofen Drug Interactions
  • Ibuprofen General Consumer Information
  • Drug Interactions Checker
Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some mixtures of medications can lead to serious and even fatal consequences.

View drug interactions between cannabis and ibuprofen. These medicines may also interact with certain foods or diseases.

Mix Pot and Ibuprofen; Lose the Buzz

Marijuana was first a recreational drug in the United States, grown for high-levels of buzz-giving THC. With the growth of the medical marijuana industry, however – now legal in 20 states – that high is often seen as an inconvenient side effect when it comes to serious medical treatment. A new study suggests there may be a way to give patients the help they need, and only that: Pairing THC with ibuprofen, it turns out, can keep the health benefits but get rid of the high.

–> Until recently, researchers have been unable to separate the different effects of THC. The notorious high was part and parcel with the painkilling and anti-inflammatory benefits, as were the detrimental effects on long-term memory and neuronal circuitry. But scientists found that when they block a particular enzyme called COX-2 (which ibuprofen or drugs like Celebrex do), the treatment benefits of THC remained, but the high – and the neurological side effects – disappeared.

When scientists added THC and a COX-2 blocker to isolated neurons, they saw that the cells remained healthy – whereas, with THC alone, the cells often begin to have trouble forming connections, something that likely contributes to the memory and cognitive problems seen with long-term pot use. The scientists also gave THC to regular mice and mice genetically engineered not to make COX-2 at all – the biological equivalent of a COX-2 blocker. While regular mice were sluggish, barely moving around their cages, the mice without COXO-2 didn’t show any signs of a high.

Chen hopes a similar combination may soon be prescribed for human patients, too. There’s possibility here for a simple, and sober, drug cocktail: “You could take a COX-2 inhibitor or an OTC painkiller with THC to treat a variety of medical conditions, like epilepsy or multiple sclerosis,” he says. And while his study didn’t look particularly at THC’s analgesic effects, it’s likely this could also work to give people THC’s much-touted pain relief, without the buzz.

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A new study finds that taking ibuprofen with marijuana may do away with the high.